View source for 11lr


==Human monoclonal antibody 8C5 in complex with rabies virus glycoprotein==
<StructureSection load='11lr' size='340' side='right'caption='[[11lr]], [[Resolution|resolution]] 3.16&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[11lr]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rabies_lyssavirus Rabies lyssavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=11LR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=11LR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.16&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=11lr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=11lr OCA], [https://pdbe.org/11lr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=11lr RCSB], [https://www.ebi.ac.uk/pdbsum/11lr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=11lr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GLYCO_RABVP GLYCO_RABVP] Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells (By similarity).
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Rabies lyssavirus]]
[[Category: Bouhry H]]
[[Category: Callaway HM]]
[[Category: Corti D]]
[[Category: Dessain S]]
[[Category: Flynn A]]
[[Category: Hariharan C]]
[[Category: Harkins S]]
[[Category: Hastie K]]
[[Category: Kothalawalage S]]
[[Category: Samarasinghe S]]
[[Category: Saphire EO]]
[[Category: Yin J]]
[[Category: Zyla D]]