View source for 11nq


==Crystal structure of viral OTU domain protease from Songling Virus==
<StructureSection load='11nq' size='340' side='right'caption='[[11nq]], [[Resolution|resolution]] 1.22&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[11nq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Orthonairovirus_songlingense Orthonairovirus songlingense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=11NQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=11NQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.22&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=11nq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=11nq OCA], [https://pdbe.org/11nq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=11nq RCSB], [https://www.ebi.ac.uk/pdbsum/11nq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=11nq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A7U3T2V7_9VIRU A0A7U3T2V7_9VIRU] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Tick-borne negative-sense single-stranded RNA nairoviruses represent a significant global public-health threat. Over the past decade, discoveries of new orthonairoviruses and norwaviruses have surged. Many of these have been observed to cause febrile illness in humans or have been found in vectors that carry other human diseases. All orthonairoviruses encode a viral homologue of the ovarian tumor protease (OTU) superfamily, which is part of the l-protein, and the OTU is conserved in the Norwavirus genus. OTUs exhibit varying levels of deubiquitinating (DUB) and deISGylating activities that facilitate viral immune evasion, establishing them as key virulence factors. Here, these activities from emerging Songling, Yezo, Tacheng tick virus 1, and Pacific Coast Tick orthonairoviruses, as well as the Beiji norwavirus, were investigated. This analysis reveals a diverse range of DUB and human deISGylase enzymatic activities in the previously uncharacterized viral groups. This includes unexpected OTU human deISGylating activity and suggests that OTUs possess functions beyond their established DUB and deISGylating roles. Additionally, the molecular basis of these activities, or the absence thereof, is explored through X-ray crystallographic structures of viral OTUs encoded by four orthonairoviruses and one norwavirus. The biochemical and structural insights provide a path forward for predicting OTU activity among current and emerging nairoviruses.

Insights into the Structure and Function of the OTU Protease Virulence Factors from Emerging Human Nairoviruses.,Gonzalez DS, Jalf A, Moresco V, Garcia J, Jaroszewski L, Matta D, Nguyen J, Torres B, Bergeron E, Godzik A, Pegan SD ACS Infect Dis. 2026 Jul 13. doi: 10.1021/acsinfecdis.6c00320. PMID:42439547<ref>PMID:42439547</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 11nq" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Orthonairovirus songlingense]]
[[Category: Gonzalez DS]]
[[Category: Pegan SD]]