View source for 11pu


==Crystal Structure of viral OTU domain protease from Beiji nairovirus==
<StructureSection load='11pu' size='340' side='right'caption='[[11pu]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[11pu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Norwavirus_beijiense Norwavirus beijiense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=11PU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=11PU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=11pu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=11pu OCA], [https://pdbe.org/11pu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=11pu RCSB], [https://www.ebi.ac.uk/pdbsum/11pu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=11pu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0AAX2ZL03_9VIRU A0AAX2ZL03_9VIRU] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Tick-borne negative-sense single-stranded RNA nairoviruses represent a significant global public-health threat. Over the past decade, discoveries of new orthonairoviruses and norwaviruses have surged. Many of these have been observed to cause febrile illness in humans or have been found in vectors that carry other human diseases. All orthonairoviruses encode a viral homologue of the ovarian tumor protease (OTU) superfamily, which is part of the l-protein, and the OTU is conserved in the Norwavirus genus. OTUs exhibit varying levels of deubiquitinating (DUB) and deISGylating activities that facilitate viral immune evasion, establishing them as key virulence factors. Here, these activities from emerging Songling, Yezo, Tacheng tick virus 1, and Pacific Coast Tick orthonairoviruses, as well as the Beiji norwavirus, were investigated. This analysis reveals a diverse range of DUB and human deISGylase enzymatic activities in the previously uncharacterized viral groups. This includes unexpected OTU human deISGylating activity and suggests that OTUs possess functions beyond their established DUB and deISGylating roles. Additionally, the molecular basis of these activities, or the absence thereof, is explored through X-ray crystallographic structures of viral OTUs encoded by four orthonairoviruses and one norwavirus. The biochemical and structural insights provide a path forward for predicting OTU activity among current and emerging nairoviruses.

Insights into the Structure and Function of the OTU Protease Virulence Factors from Emerging Human Nairoviruses.,Gonzalez DS, Jalf A, Moresco V, Garcia J, Jaroszewski L, Matta D, Nguyen J, Torres B, Bergeron E, Godzik A, Pegan SD ACS Infect Dis. 2026 Jul 13. doi: 10.1021/acsinfecdis.6c00320. PMID:42439547<ref>PMID:42439547</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 11pu" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Norwavirus beijiense]]
[[Category: Gonzalez DS]]
[[Category: Pegan SD]]