View source for 11sy


==Cryo-EM structure of substrate engaged p97-Ufd1-NPL4-Faf1 complex (NPL4 focused)==
<StructureSection load='11sy' size='340' side='right'caption='[[11sy]], [[Resolution|resolution]] 4.28&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[11sy]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=11SY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=11SY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.28&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=11sy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=11sy OCA], [https://pdbe.org/11sy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=11sy RCSB], [https://www.ebi.ac.uk/pdbsum/11sy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=11sy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NPL4_HUMAN NPL4_HUMAN] The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (PubMed:26471729).[UniProtKB:Q9ES54]<ref>PMID:26471729</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Liao Z]]
[[Category: Martin A]]