View source for 12bl


==Moorella thermoacetica LarC in complex with P2TAD==
<StructureSection load='12bl' size='340' side='right'caption='[[12bl]], [[Resolution|resolution]] 3.33&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[12bl]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Moorella_thermoacetica_ATCC_39073 Moorella thermoacetica ATCC 39073]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=12BL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=12BL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.33&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1DCH:1-[(2~{R},3~{R},4~{S},5~{R})-5-[[[[(2~{R},3~{S},4~{S})-5-(6-aminopurin-9-yl)-2,3,4-tris(oxidanyl)pentoxy]-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-3,4-bis(oxidanyl)oxolan-2-yl]pyridin-1-ium-3,5-dicarbothioic+S-acid'>A1DCH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=12bl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=12bl OCA], [https://pdbe.org/12bl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=12bl RCSB], [https://www.ebi.ac.uk/pdbsum/12bl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=12bl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LARC_MOOTA LARC_MOOTA] Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Moorella thermoacetica ATCC 39073]]
[[Category: Kim KH]]
[[Category: Wolfe R]]