View source for 12vd


==WT Human Aconitate Decarboxylase 1, citraconate-bound==
<StructureSection load='12vd' size='340' side='right'caption='[[12vd]], [[Resolution|resolution]] 1.22&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[12vd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=12VD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=12VD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.22&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CIZ:(~{Z})-2-METHYLBUT-2-ENEDIOIC+ACID'>CIZ</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=12vd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=12vd OCA], [https://pdbe.org/12vd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=12vd RCSB], [https://www.ebi.ac.uk/pdbsum/12vd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=12vd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IRG1_HUMAN IRG1_HUMAN] Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.<ref>PMID:23609450</ref> <ref>PMID:23610393</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Monteiro DCF]]
[[Category: Runge B]]