View source for 13er


==Cryo-EM structure of HAdV-C6 hexon trimer in complex with prothrombin (FII)==
<StructureSection load='13er' size='340' side='right'caption='[[13er]], [[Resolution|resolution]] 3.22&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[13er]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_adenovirus_6 Human adenovirus 6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=13ER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=13ER FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.22&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=13er FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=13er OCA], [https://pdbe.org/13er PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=13er RCSB], [https://www.ebi.ac.uk/pdbsum/13er PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=13er ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/B2ZWX4_ADE06 B2ZWX4_ADE06] Major capsid protein that self-associates to form 240 hexon trimers, each in the shape of a hexagon, building most of the pseudo T=25 capsid. Assembled into trimeric units with the help of the chaperone shutoff protein. Transported by pre-protein VI to the nucleus where it associates with other structural proteins to form an empty capsid. Might be involved, through its interaction with host dyneins, in the intracellular microtubule-dependent transport of incoming viral capsid to the nucleus.[ARBA:ARBA00024662][HAMAP-Rule:MF_04051]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Human adenovirus 6]]
[[Category: Large Structures]]
[[Category: Ma OX]]
[[Category: Reddy VS]]