View source for 13jv


==Cryo-EM structure of the mature SLEV, asymmetric unit==
<StructureSection load='13jv' size='340' side='right'caption='[[13jv]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[13jv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saint_Louis_encephalitis_virus Saint Louis encephalitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=13JV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=13JV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>3PE</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=13jv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=13jv OCA], [https://pdbe.org/13jv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=13jv RCSB], [https://www.ebi.ac.uk/pdbsum/13jv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=13jv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A0A0WEU2_9FLAV A0A0A0WEU2_9FLAV] Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[ARBA:ARBA00003504]  May play a role in virus budding. Exerts cytotoxic effects by activating a mitochondrial apoptotic pathway through M ectodomain. May display a viroporin activity.[ARBA:ARBA00035609]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saint Louis encephalitis virus]]
[[Category: Benedetti C]]
[[Category: Coimbra LD]]
[[Category: Guimaraes SL]]
[[Category: Marques RE]]