View source for 1a92


==OLIGOMERIZATION DOMAIN OF HEPATITIS DELTA ANTIGEN==
<StructureSection load='1a92' size='340' side='right'caption='[[1a92]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1a92]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_delta_virus Hepatitis delta virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A92 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a92 OCA], [https://pdbe.org/1a92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a92 RCSB], [https://www.ebi.ac.uk/pdbsum/1a92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a92 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SHDAG_HDVAM SHDAG_HDVAM] Promotes both transcription and replication of genomic RNA. Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. May interact with host RNA polymerase II thereby changing its template requirement from DNA to RNA. RNA pol II complex would then acts as an RNA-directed RNA polymerase, and transcribe and replicate HDV genome (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a9/1a92_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a92 ConSurf].
<div style="clear:both"></div>
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</StructureSection>
[[Category: Hepatitis delta virus]]
[[Category: Large Structures]]
[[Category: Hogle JM]]
[[Category: Zuccola HJ]]