View source for 1den


==PROTEINASE INHIBITOR HOMOLOGUES AS POTASSIUM CHANNEL BLOCKERS==
<StructureSection load='1den' size='340' side='right'caption='[[1den]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1den]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_polylepis_polylepis Dendroaspis polylepis polylepis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DEN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DEN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1den FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1den OCA], [https://pdbe.org/1den PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1den RCSB], [https://www.ebi.ac.uk/pdbsum/1den PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1den ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VKTH1_DENPO VKTH1_DENPO] Serine protease inhibitor homolog that blocks voltage-gated potassium channels (Kv1.1/KCNA1, Kv1.2/KCNA2, and Kv1.6/KCNA6) (IC(50)=0.13-50 nM).<ref>PMID:8612784</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/de/1den_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1den ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Dendrotoxin|Dendrotoxin]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Dendroaspis polylepis polylepis]]
[[Category: Large Structures]]
[[Category: Foray M-F]]
[[Category: Lancelin J-M]]