View source for 1evb


==NMR structure of cyanobacterial toxin, phosphatase-1/-2A inhibitor==
<StructureSection load='1evb' size='340' side='right'caption='[[1evb]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1evb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Microcystis Microcystis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EVB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1ZN:(2S,3S,4E,6E,8S,9S)-3-AMINO-9-METHOXY-2,6,8-TRIMETHYL-10-PHENYLDECA-4,6-DIENOIC+ACID'>1ZN</scene>, <scene name='pdbligand=ACB:3-METHYL-BETA-D-ASPARTIC+ACID'>ACB</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DAM:N-METHYL-ALPHA-BETA-DEHYDROALANINE'>DAM</scene>, <scene name='pdbligand=FGA:GAMMA-D-GLUTAMIC+ACID'>FGA</scene>, <scene name='pdbligand=PRD_000212:Microcystin+LR'>PRD_000212</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1evb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1evb OCA], [https://pdbe.org/1evb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1evb RCSB], [https://www.ebi.ac.uk/pdbsum/1evb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1evb ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
A comparison of the structures of two cyanobacterial toxins yields insights into how they may inhibit protein phosphatase-1 and -2A and why microcystins but not motuporin may covalently modify their protein phosphatase targets.

Comparison of the solution structures of microcystin-LR and motuporin.,Bagu JR, Sonnichsen FD, Williams D, Andersen RJ, Sykes BD, Holmes CF Nat Struct Biol. 1995 Feb;2(2):114-6. PMID:7749913<ref>PMID:7749913</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1evb" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Microcystis]]
[[Category: Bagu JR]]
[[Category: Sykes BD]]