View source for 1flg


==CRYSTAL STRUCTURE OF THE QUINOPROTEIN ETHANOL DEHYDROGENASE FROM PSEUDOMONAS AERUGINOSA==
<StructureSection load='1flg' size='340' side='right'caption='[[1flg]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1flg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1eee 1eee]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FLG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FLG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PQQ:PYRROLOQUINOLINE+QUINONE'>PQQ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1flg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1flg OCA], [https://pdbe.org/1flg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1flg RCSB], [https://www.ebi.ac.uk/pdbsum/1flg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1flg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/QEDH_PSEAE QEDH_PSEAE] Catalyzes the oxidation of ethanol and other primary alcohols to the corresponding aldehydes, except methanol, which is a very poor substrate. Uses a specific inducible cytochrome c550, encoded by the adjacent gene in the locus, as electron acceptor. Is a key enzyme of the carbon and energy metabolism during growth of P.aeruginosa on ethanol as the sole carbon and energy source. Is also able to use secondary alcohols as well as aminoalcohols like ethanolamine and 1-amino-2-propanol, and aldehydes as substrates.<ref>PMID:19224199</ref> <ref>PMID:3144289</ref> <ref>PMID:8380982</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fl/1flg_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1flg ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Diehl A]]
[[Category: Gorisch H]]
[[Category: Hohne W]]
[[Category: Keitel T]]
[[Category: Knaute T]]
[[Category: Stezowski JJ]]