View source for 1gea


==RECEPTOR-BOUND CONFORMATION OF PACAP21==
<StructureSection load='1gea' size='340' side='right'caption='[[1gea]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1gea]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GEA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GEA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LYN:2,6-DIAMINO-HEXANOIC+ACID+AMIDE'>LYN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gea OCA], [https://pdbe.org/1gea PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gea RCSB], [https://www.ebi.ac.uk/pdbsum/1gea PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gea ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PACA_HUMAN PACA_HUMAN] Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells.<ref>PMID:11175907</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Many peptide hormones elicit a wide array of physiological effects by binding to G-protein coupled receptors. We have determined the conformation of pituitary adenylate cyclase activating polypeptide, PACAP(1--21)NH(2), bound to a PACAP-specific receptor by NMR spectroscopy. Residues 3--7 form a unique beta-coil structure that is preceded by an N-terminal extended tail. This beta-coil creates a patch of hydrophobic residues that is important for receptor binding. In contrast, the C-terminal region (residues 8--21) forms an alpha-helix, similar to that in the micelle-bound PACAP. Thus, the conformational difference between PACAP in the receptor-bound and the micelle-bound states is limited to the N-terminal seven residues. This observation is consistent with the two-step ligand transportation model in which PACAP first binds to the membrane nonspecifically and then diffuses two-dimensionally in search of its receptor; a conformational change at the N-terminal region then allows specific interactions between the ligand and the receptor.

Conformation of a peptide ligand bound to its G-protein coupled receptor.,Inooka H, Ohtaki T, Kitahara O, Ikegami T, Endo S, Kitada C, Ogi K, Onda H, Fujino M, Shirakawa M Nat Struct Biol. 2001 Feb;8(2):161-5. PMID:11175907<ref>PMID:11175907</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1gea" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Endo S]]
[[Category: Fujino M]]
[[Category: Ikegami T]]
[[Category: Inooka H]]
[[Category: Kitada C]]
[[Category: Kitahara O]]
[[Category: Ogi K]]
[[Category: Ohtaki T]]
[[Category: Onda H]]
[[Category: Shirakawa M]]