View source for 1ieo


==SOLUTION STRUCTURE OF MRIB-NH2==
<StructureSection load='1ieo' size='340' side='right'caption='[[1ieo]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1ieo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_marmoreus Conus marmoreus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IEO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IEO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ieo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ieo OCA], [https://pdbe.org/1ieo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ieo RCSB], [https://www.ebi.ac.uk/pdbsum/1ieo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ieo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CTA1B_CONMR CTA1B_CONMR] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Cone snails use venom containing a cocktail of peptides ('conopeptides') to capture their prey. Many of these peptides also target mammalian receptors, often with exquisite selectivity. Here we report the discovery of two new classes of conopeptides. One class targets alpha1-adrenoceptors (rho-TIA from the fish-hunting Conus tulipa), and the second class targets the neuronal noradrenaline transporter (chi-MrIA and chi-MrIB from the mollusk-hunting C. marmoreus). rho-TIA and chi-MrIA selectively modulate these important membrane-bound proteins. Both peptides act as reversible non-competitive inhibitors and provide alternative avenues for the identification of inhibitor drugs.

Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter.,Sharpe IA, Gehrmann J, Loughnan ML, Thomas L, Adams DA, Atkins A, Palant E, Craik DJ, Adams DJ, Alewood PF, Lewis RJ Nat Neurosci. 2001 Sep;4(9):902-7. PMID:11528421<ref>PMID:11528421</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1ieo" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Conus marmoreus]]
[[Category: Large Structures]]
[[Category: Adams DA]]
[[Category: Adams DJ]]
[[Category: Alewood PF]]
[[Category: Atkins A]]
[[Category: Craik DJ]]
[[Category: Gehrmann J]]
[[Category: Lewis RJ]]
[[Category: Loughnan ML]]
[[Category: Palant E]]
[[Category: Sharpe IA]]
[[Category: Thomas L]]