View source for 1iq3


==SOLUTION STRUCTURE OF THE EPS15 HOMOLOGY DOMAIN OF A HUMAN POB1==
<StructureSection load='1iq3' size='340' side='right'caption='[[1iq3]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1iq3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IQ3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iq3 OCA], [https://pdbe.org/1iq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iq3 RCSB], [https://www.ebi.ac.uk/pdbsum/1iq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iq3 ProSAT], [https://www.topsan.org/Proteins/RSGI/1iq3 TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/REPS2_HUMAN REPS2_HUMAN] Involved in growth factor signaling through its influence on the Ral signaling pathway.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iq/1iq3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1iq3 ConSurf].
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== Publication Abstract from PubMed ==
The solution structure of the Eps15 homology (EH) domain of a human POB1 (partner of RaIBP1) has been determined by uniform 13C/15N labeling and heteronuclear multidimensional nuclear magnetic resonance spectroscopy. The POB1 EH domain consists of two EF-hand structures, and the second one binds a calcium ion. In the calcium-bound state, the orientation of the fourth alpha-helix relative to the other helices of the POB1 EH domain is slightly different from that of calbindin, and much more different from those of calmodulin and troponin C, on the basis of their atomic coordinates.

Solution structure of the Eps15 homology domain of a human POB1 (partner of RalBP1).,Koshiba S, Kigawa T, Iwahara J, Kikuchi A, Yokoyama S FEBS Lett. 1999 Jan 15;442(2-3):138-42. PMID:9928989<ref>PMID:9928989</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1iq3" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Iwahara J]]
[[Category: Kigawa T]]
[[Category: Kikuchi A]]
[[Category: Koshiba S]]
[[Category: Yokoyama S]]