View source for 1iqo


==Solution structure of MTH1880 from methanobacterium thermoautotrophicum==
<StructureSection load='1iqo' size='340' side='right'caption='[[1iqo]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1iqo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter Methanothermobacter]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IQO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IQO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iqo OCA], [https://pdbe.org/1iqo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iqo RCSB], [https://www.ebi.ac.uk/pdbsum/1iqo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iqo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/O27908_METTH O27908_METTH] 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iq/1iqo_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1iqo ConSurf].
<div style="clear:both"></div>
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== Publication Abstract from PubMed ==
MTH1880 is a hypothetical protein from Methanobacterium thermoautotrophicum, a target organism of structural genomics. The solution structure determined by NMR spectroscopy demonstrates a typical alpha + beta-fold found in many proteins with different functions. The molecular surface of the protein reveals a small, highly acidic pocket comprising loop B (Asp36, Asp37, Asp38), the end of beta2 (Glu39), and loop D (Ser57, Ser58, Ser61), indicating that the protein would have a possible cation binding site. The NMR resonances of several amino acids within the acidic binding pocket in MTH1880, shifted upon addition of calcium ion. This calcium binding motif and overall topology of MTH1880 differ from those of other calcium binding proteins. MTH1880 did not show a calcium-induced conformational change typical of calcium sensor proteins. Therefore, we propose that the MTH1880 protein contains a novel motif for calcium-specific binding, and may function as a calcium buffering protein.

Solution structure of a novel calcium binding protein, MTH1880, from Methanobacterium thermoautotrophicum.,Lee CH, Jung JW, Yee A, Arrowsmith CH, Lee W Protein Sci. 2004 Apr;13(4):1148-54. PMID:15044740<ref>PMID:15044740</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1iqo" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Methanothermobacter]]
[[Category: Arrowsmith CH]]
[[Category: Bang E]]
[[Category: Jung JW]]
[[Category: Lee CH]]
[[Category: Lee W]]
[[Category: Shin J]]
[[Category: Yee A]]