View source for 1irg


==INTERFERON REGULATORY FACTOR-2 DNA BINDING DOMAIN, NMR, 20 STRUCTURES==
<StructureSection load='1irg' size='340' side='right'caption='[[1irg]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1irg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IRG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IRG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1irg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1irg OCA], [https://pdbe.org/1irg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1irg RCSB], [https://www.ebi.ac.uk/pdbsum/1irg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1irg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IRF2_MOUSE IRF2_MOUSE] Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ir/1irg_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1irg ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Interferon regulatory factor|Interferon regulatory factor]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Furui J]]
[[Category: Harada H]]
[[Category: Kyogoku Y]]
[[Category: Shirakawa M]]
[[Category: Swindells MB]]
[[Category: Taniguchi T]]
[[Category: Uegaki K]]
[[Category: Yamazaki T]]