View source for 1jrf


==NMR Solution Structure of the Viral Receptor Domain of Tva==
<StructureSection load='1jrf' size='340' side='right'caption='[[1jrf]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1jrf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Coturnix_japonica Coturnix japonica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JRF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jrf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jrf OCA], [https://pdbe.org/1jrf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jrf RCSB], [https://www.ebi.ac.uk/pdbsum/1jrf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jrf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RSVR_COTJA RSVR_COTJA] Responsible for susceptibility to the retrovirus subgroup A Rous sarcoma virus.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jr/1jrf_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jrf ConSurf].
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== Publication Abstract from PubMed ==
Tva is the cellular receptor for subgroup A avian sarcoma and leukosis virus (ASLV-A). The viral receptor function of Tva is determined by a 40-residue, cysteine-rich motif called the LDL-A module. Here we report the solution structure of the LDL-A module of Tva, determined by nuclear magnetic resonance (NMR) spectroscopy. Although the carboxyl terminus of the Tva LDL-A module has a structure similar to those of other reported LDL-A modules, the amino terminus adopts a different conformation. The LDL-A module of Tva does not contain the signature antiparallel beta-sheet observed in other LDL-A modules, and it is more flexible than other reported LDL-A modules. The LDL-A structure of Tva provides mechanistic insights into how a simple viral receptor functions in retrovirus entry. The side chains of H38 and W48 of Tva, which have been identified as viral contact residues by mutational analysis, are solvent exposed, suggesting that they are directly involved in EnvA binding. However, the side chain of L34, another potential viral contact residue identified previously, is buried inside of the module and forms the hydrophobic core with other residues. Thus L34 likely stabilizes the Tva structure but is not a viral interaction determinant. In addition, we propose that the flexible amino-terminal region of Tva plays an important role in determining specificity in the Tva-EnvA interaction.

Solution structure of the viral receptor domain of Tva and its implications in viral entry.,Wang QY, Huang W, Dolmer K, Gettins PG, Rong L J Virol. 2002 Mar;76(6):2848-56. PMID:11861852<ref>PMID:11861852</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Coturnix japonica]]
[[Category: Large Structures]]
[[Category: Dolmer K]]
[[Category: Gettins PGW]]
[[Category: Huang W]]
[[Category: Rong L]]
[[Category: Wang Q-Y]]