View source for 1k46


==Crystal Structure of the Type III Secretory Domain of Yersinia YopH Reveals a Domain-Swapped Dimer==
<StructureSection load='1k46' size='340' side='right'caption='[[1k46]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1k46]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pseudotuberculosis Yersinia pseudotuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K46 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K46 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k46 OCA], [https://pdbe.org/1k46 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k46 RCSB], [https://www.ebi.ac.uk/pdbsum/1k46 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k46 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/YOPH_YERPS YOPH_YERPS] Essential virulence determinant. This protein is a protein tyrosine phosphatase. The essential function of YopH in Yersinia pathogenesis is host-protein dephosphorylation. It contributes to the ability of the bacteria to resist phagocytosis by peritoneal macrophages.

==See Also==
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Yersinia pseudotuberculosis]]
[[Category: Keliikuli K]]
[[Category: Khandelwal P]]
[[Category: Saper MA]]
[[Category: Smith CL]]
[[Category: Zuiderweg ERP]]