View source for 1kke


==Crystal Structure of Reovirus Attachment Protein Sigma1 Trimer==
<StructureSection load='1kke' size='340' side='right'caption='[[1kke]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1kke]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mammalian_orthoreovirus_3_Dearing Mammalian orthoreovirus 3 Dearing]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KKE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kke OCA], [https://pdbe.org/1kke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kke RCSB], [https://www.ebi.ac.uk/pdbsum/1kke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kke ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SIGM1_REOVD SIGM1_REOVD] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kk/1kke_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kke ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mammalian orthoreovirus 3 Dearing]]
[[Category: Chappell JD]]
[[Category: Dermody TS]]
[[Category: Prota AE]]
[[Category: Stehle T]]