View source for 1kt1


==Structure of the Large FKBP-like Protein, FKBP51, Involved in Steroid Receptor Complexes==
<StructureSection load='1kt1' size='340' side='right'caption='[[1kt1]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1kt1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saimiri_boliviensis Saimiri boliviensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KT1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KT1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kt1 OCA], [https://pdbe.org/1kt1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kt1 RCSB], [https://www.ebi.ac.uk/pdbsum/1kt1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kt1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FKBP5_SAIBB FKBP5_SAIBB] Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP (By similarity). Interacts with the glucocorticoid receptor and modulates its response to glucocorticoids.<ref>PMID:11089542</ref> <ref>PMID:12538866</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kt/1kt1_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kt1 ConSurf].
<div style="clear:both"></div>

==See Also==
*[[FKBP 3D structures|FKBP 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saimiri boliviensis]]
[[Category: Cheung-Flynn J]]
[[Category: Clardy JC]]
[[Category: Rimerman RA]]
[[Category: Scammell JG]]
[[Category: Sinars CR]]
[[Category: Smith DF]]