View source for 1nti


==RDC-refined NMR structure of bovine Acyl-coenzyme A Binding Protein, ACBP==
<StructureSection load='1nti' size='340' side='right'caption='[[1nti]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1nti]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NTI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nti OCA], [https://pdbe.org/1nti PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nti RCSB], [https://www.ebi.ac.uk/pdbsum/1nti PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nti ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ACBP_BOVIN ACBP_BOVIN] Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.<ref>PMID:11491287</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nt/1nti_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nti ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Large Structures]]
[[Category: Kragelund BB]]
[[Category: Lerche MH]]
[[Category: Poulsen FM]]
[[Category: Redfield C]]