View source for 1pm4


==Crystal structure of Yersinia pseudotuberculosis-derived mitogen (YPM)==
<StructureSection load='1pm4' size='340' side='right'caption='[[1pm4]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1pm4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pseudotuberculosis Yersinia pseudotuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PM4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.755&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pm4 OCA], [https://pdbe.org/1pm4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pm4 RCSB], [https://www.ebi.ac.uk/pdbsum/1pm4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pm4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q57221_YERPU Q57221_YERPU] 
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== Publication Abstract from PubMed ==
Superantigens are a class of microbial proteins with the ability to excessively activate T cells by binding to the T cell receptor. The staphylococcal and streptococcal superantigens are closely related in structure and possess an N-terminal domain that resembles an OB fold and a C-terminal domain similar to a beta-grasp fold. Yersinia pseudotuberculosis produces superantigens, YPMa, YPMb, and YPMc, which have no significant amino acid similarity to other proteins. We have determined the crystal and solution structures of YPMa, which show that the protein has a jelly-roll fold. The closest structural neighbors to YPMa are viral capsid proteins and members of the tumor necrosis factor superfamily. In the crystal structure, YPMa packs as a trimer, another feature shared with viral capsid proteins and TNF superfamily proteins. However, in solution YPMa behaves as a monomer, and any functional relevance of the trimer observed in the crystals is yet to be established.

Crystal and solution structures of a superantigen from Yersinia pseudotuberculosis reveal a jelly-roll fold.,Donadini R, Liew CW, Kwan AH, Mackay JP, Fields BA Structure. 2004 Jan;12(1):145-56. PMID:14725774<ref>PMID:14725774</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1pm4" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Yersinia pseudotuberculosis]]
[[Category: Donadini R]]
[[Category: Fields BA]]
[[Category: Kwan AH]]
[[Category: Liew CW]]
[[Category: Mackay JP]]