View source for 1qjk


==Metallothionein MTA from sea urchin (alpha domain)==
<StructureSection load='1qjk' size='340' side='right'caption='[[1qjk]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1qjk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Strongylocentrotus_purpuratus Strongylocentrotus purpuratus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QJK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QJK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qjk OCA], [https://pdbe.org/1qjk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qjk RCSB], [https://www.ebi.ac.uk/pdbsum/1qjk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qjk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MTA_STRPU MTA_STRPU] Metallothioneins have a high content of cysteine residues that bind various heavy metals.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The three-dimensional structure of [(113)Cd7]-metallothionein-A (MTA) of the sea urchin Strongylocentrotus purpuratus was determined by homonuclear(1)H NMR experiments and heteronuclear [(1)H, (113)Cd]-correlation spectroscopy. MTA is composed of two globular domains, an N-terminal four-metal domain of the amino acid residues 1 to 36 and a Cd4Cys11cluster, and a C-terminal three-metal domain including the amino acid residues 37 to 65 and a Cd3Cys9cluster. The structure resembles the known mammalian and crustacean metallothioneins, but has a significantly different connectivity pattern of the Cys-metal co-ordination bonds and concomitantly contains novel local folds of some polypeptide backbone segments. These differences can be related to variations of the Cys sequence positions and thus emphasize the special role of the cysteine residues in defining the structure of metallothioneins, both on the level of the domain architecture and the topology of the metal-thiolate clusters.

NMR structure of the sea urchin (Strongylocentrotus purpuratus) metallothionein MTA.,Riek R, Precheur B, Wang Y, Mackay EA, Wider G, Guntert P, Liu A, Kagi JH, Wuthrich K J Mol Biol. 1999 Aug 13;291(2):417-28. PMID:10438629<ref>PMID:10438629</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1qjk" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Strongylocentrotus purpuratus]]
[[Category: Guntert P]]
[[Category: Kaegi JHR]]
[[Category: Liu A]]
[[Category: Mackay EA]]
[[Category: Precheur B]]
[[Category: Riek R]]
[[Category: Wang Y]]
[[Category: Wider G]]
[[Category: Wuthrich K]]