View source for 1qyd


==Crystal structures of pinoresinol-lariciresinol and phenylcoumaran benzylic ether reductases, and their relationship to isoflavone reductases==
<StructureSection load='1qyd' size='340' side='right'caption='[[1qyd]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1qyd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thuja_plicata Thuja plicata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QYD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QYD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qyd OCA], [https://pdbe.org/1qyd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qyd RCSB], [https://www.ebi.ac.uk/pdbsum/1qyd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qyd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PILR1_THUPL PILR1_THUPL] Reductase involved in lignan biosynthesis. Catalyzes the enantioselective sequential conversion of (-)-pinoresinol into (-)-lariciresinol and of (-)-lariciresinol into (+)-secoisolariciresinol. Can also convert with a lower efficiency (+)-pinoresinol into (+)-lariciresinol, but not (+)-lariciresinol into (-)-secoisolariciresinol. Abstracts the 4R-hydride from the NADPH cofactor during catalysis.<ref>PMID:9872995</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qy/1qyd_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qyd ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thuja plicata]]
[[Category: Bedgar DL]]
[[Category: Davin LB]]
[[Category: Gang DR]]
[[Category: Halls SC]]
[[Category: Hilsenbeck JL]]
[[Category: Kang C]]
[[Category: Kasahara H]]
[[Category: Lawrence PK]]
[[Category: Min T]]
[[Category: Park H]]
[[Category: Youn B]]