View source for 1sso


==SOLUTION STRUCTURE AND DNA-BINDING PROPERTIES OF A THERMOSTABLE PROTEIN FROM THE ARCHAEON SULFOLOBUS SOLFATARICUS==
<StructureSection load='1sso' size='340' side='right'caption='[[1sso]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1sso]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SSO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SSO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sso OCA], [https://pdbe.org/1sso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sso RCSB], [https://www.ebi.ac.uk/pdbsum/1sso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sso ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DN7A_SACS2 DN7A_SACS2] 
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== Publication Abstract from PubMed ==
The archaeon Sulfolobus solfataricus expresses large amounts of a small basic protein, Sso7d, which was previously identified as a DNA-binding protein possibly involved in compaction of DNA. We have determined the solution structure of Sso7d. The protein consists of a triple-stranded anti-parallel beta-sheet onto which an orthogonal double-stranded beta-sheet is packed. This topology is very similar to that found in eukaryotic Src homology-3 (SH3) domains. Sso7d binds strongly (Kd &lt; 10 microM) to double-stranded DNA and protects it from thermal denaturation. In addition, we note that epsilon-mono-methylation of lysine side chains of Sso7d is governed by cell growth temperatures, suggesting that methylation is related to the heat-shock response.

Solution structure and DNA-binding properties of a thermostable protein from the archaeon Sulfolobus solfataricus.,Baumann H, Knapp S, Lundback T, Ladenstein R, Hard T Nat Struct Biol. 1994 Nov;1(11):808-19. PMID:7634092<ref>PMID:7634092</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharolobus solfataricus]]
[[Category: Baumann H]]
[[Category: Hard T]]
[[Category: Knapp S]]
[[Category: Ladenstein R]]
[[Category: Lundback T]]