View source for 1tuz


==NMR Structure of the Diacylglycerol kinase alpha, NESGC target HR532==
<StructureSection load='1tuz' size='340' side='right'caption='[[1tuz]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1tuz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TUZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tuz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tuz OCA], [https://pdbe.org/1tuz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tuz RCSB], [https://www.ebi.ac.uk/pdbsum/1tuz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tuz ProSAT], [https://www.topsan.org/Proteins/NESGC/1tuz TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DGKA_HUMAN DGKA_HUMAN] Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tu/1tuz_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tuz ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Diacylglycerol kinase 3D structures|Diacylglycerol kinase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Acton T]]
[[Category: Liu G]]
[[Category: Montelione GT]]
[[Category: Shao Y]]
[[Category: Szyperski T]]
[[Category: Xiao R]]