View source for 1tw9


==Glutathione Transferase-2, apo form, from the nematode Heligmosomoides polygyrus==
<StructureSection load='1tw9' size='340' side='right'caption='[[1tw9]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1tw9]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Heligmosomoides_polygyrus Heligmosomoides polygyrus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TW9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TW9 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.71&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tw9 OCA], [https://pdbe.org/1tw9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tw9 RCSB], [https://www.ebi.ac.uk/pdbsum/1tw9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tw9 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9NJQ6_HELPZ Q9NJQ6_HELPZ] 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tw/1tw9_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tw9 ConSurf].
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== Publication Abstract from PubMed ==
The crystal structure of GST Nu2-2 (HpolGSTN2-2) from the model hookworm nematode Heligmosomoides polygyrus has been solved by the molecular replacement method and refined to a resolution of 1.71 A, providing the first structural data from a class of nematode-specific GSTs. By structural alignment with two Sigma class GSTs, glutathione could be rationally docked into the G-site of the enzyme. By comparing with all mammalian GST classes, a novel, long, and deep cleft was identified at the H-site, providing a potential site for ligand binding. This new GST class may support the establishment of infection parasitic nematodes by passively neutralizing chemical toxins derived from host environment. The structure serves as a starting point for structure-based drug/inhibitor design that would aim to selectively disrupt nematode chemical defenses.

Crystal structure of a new class of glutathione transferase from the model human hookworm nematode Heligmosomoides polygyrus.,Schuller DJ, Liu Q, Kriksunov IA, Campbell AM, Barrett J, Brophy PM, Hao Q Proteins. 2005 Dec 1;61(4):1024-31. PMID:16189827<ref>PMID:16189827</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1tw9" style="background-color:#fffaf0;"></div>

==See Also==
*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Heligmosomoides polygyrus]]
[[Category: Large Structures]]
[[Category: Barrett J]]
[[Category: Brophy PM]]
[[Category: Campbell AM]]
[[Category: Hao Q]]
[[Category: Kriksunov IA]]
[[Category: Liu Q]]
[[Category: Schuller DJ]]