View source for 1ufn


==Solution structure of the SAND domain of the putative nuclear protein homolog (5830484A20Rik)==
<StructureSection load='1ufn' size='340' side='right'caption='[[1ufn]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1ufn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UFN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UFN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ufn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ufn OCA], [https://pdbe.org/1ufn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ufn RCSB], [https://www.ebi.ac.uk/pdbsum/1ufn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ufn ProSAT], [https://www.topsan.org/Proteins/RSGI/1ufn TOPSAN]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SP110_MOUSE SP110_MOUSE] Defects in Sp110 are a cause of severely impaired resistance to infection by M.tuberculosis.<ref>PMID:15815631</ref> 
== Function ==
[https://www.uniprot.org/uniprot/SP110_MOUSE SP110_MOUSE] May act as a transcription factor. Plays a role in the innate immunity against intracellular pathogens. Required for resistance to M.tuberculosis and L.monocytogenes. Promotes apoptosis of infected cells.<ref>PMID:15815631</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uf/1ufn_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ufn ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Aoki M]]
[[Category: Arakawa T]]
[[Category: Carninci P]]
[[Category: Hayashizaki Y]]
[[Category: Hirota H]]
[[Category: Inoue M]]
[[Category: Kawai J]]
[[Category: Kigawa T]]
[[Category: Kobayashi N]]
[[Category: Koshiba S]]
[[Category: Matsuda T]]
[[Category: Matsuo Y]]
[[Category: Osanai T]]
[[Category: Seki E]]
[[Category: Shirouzu M]]
[[Category: Tanaka A]]
[[Category: Terada T]]
[[Category: Tochio N]]
[[Category: Yabuki T]]
[[Category: Yokoyama S]]
[[Category: Yoshida M]]