View source for 1uhr


==Solution structure of the SWIB domain of mouse BRG1-associated factor 60a==
<StructureSection load='1uhr' size='340' side='right'caption='[[1uhr]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1uhr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UHR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uhr OCA], [https://pdbe.org/1uhr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uhr RCSB], [https://www.ebi.ac.uk/pdbsum/1uhr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uhr ProSAT], [https://www.topsan.org/Proteins/RSGI/1uhr TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SMRD1_MOUSE SMRD1_MOUSE] Involved in chromatin remodeling. Has a strong influence on the Vitamin D-mediated transcriptional activity from an enhancer Vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.<ref>PMID:17640523</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uh/1uhr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uhr ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Aoki M]]
[[Category: Arakawa T]]
[[Category: Carninci P]]
[[Category: Hayashizaki Y]]
[[Category: Hirota H]]
[[Category: Inoue M]]
[[Category: Kawai J]]
[[Category: Kigawa T]]
[[Category: Koshiba S]]
[[Category: Matsuda T]]
[[Category: Nameki N]]
[[Category: Osanai T]]
[[Category: Saito K]]
[[Category: Seki E]]
[[Category: Shirouzu M]]
[[Category: Tanaka A]]
[[Category: Terada T]]
[[Category: Yabuki T]]
[[Category: Yamada K]]
[[Category: Yokoyama S]]
[[Category: Yoshida M]]