View source for 1v5o


==Solution Structure of the Ubiquitin-like Domain from Mouse Hypothetical 1700011N24Rik Protein==
<StructureSection load='1v5o' size='340' side='right'caption='[[1v5o]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1v5o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V5O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V5O FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v5o OCA], [https://pdbe.org/1v5o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v5o RCSB], [https://www.ebi.ac.uk/pdbsum/1v5o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v5o ProSAT], [https://www.topsan.org/Proteins/RSGI/1v5o TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DDI1_MOUSE DDI1_MOUSE] Probable aspartic protease (By similarity). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2. Required, with DDI2, for cellular survival following replication stress. Together or redudantly with DDI2, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (By similarity).[UniProtKB:I7HUG0][UniProtKB:Q8WTU0]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v5/1v5o_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1v5o ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Inoue M]]
[[Category: Kigawa T]]
[[Category: Koshiba S]]
[[Category: Tomizawa T]]
[[Category: Yokoyama S]]
[[Category: Zhao C]]