View source for 1vcs


==Solution Structure of RSGI RUH-009, an N-Terminal Domain of Vti1a [Mus musculus]==
<StructureSection load='1vcs' size='340' side='right'caption='[[1vcs]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1vcs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VCS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VCS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vcs OCA], [https://pdbe.org/1vcs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vcs RCSB], [https://www.ebi.ac.uk/pdbsum/1vcs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vcs ProSAT], [https://www.topsan.org/Proteins/RSGI/1vcs TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VTI1A_MOUSE VTI1A_MOUSE] V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be concerned with increased secretion of cytokines associated with cellular senescence.<ref>PMID:19138172</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vc/1vcs_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vcs ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Abe T]]
[[Category: Hirota H]]
[[Category: Kigawa T]]
[[Category: Koshiba S]]
[[Category: Tomizawa T]]
[[Category: Yokoyama S]]