View source for 1vtg


==THE MOLECULAR STRUCTURE OF A DNA-TRIOSTIN A COMPLEX==
<StructureSection load='1vtg' size='340' side='right'caption='[[1vtg]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1vtg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_sp. Streptomyces sp.] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VTG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VTG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DSN:D-SERINE'>DSN</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=NCY:N-METHYLCYSTEINE'>NCY</scene>, <scene name='pdbligand=QUI:2-CARBOXYQUINOXALINE'>QUI</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vtg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vtg OCA], [https://pdbe.org/1vtg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vtg RCSB], [https://www.ebi.ac.uk/pdbsum/1vtg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vtg ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
The molecular structure of triostin A, a cyclic octadepsipeptide antibiotic, has been solved complexed to a DNA double helical fragment with the sequence CGTACG (C, cytosine; G, guanine; T, thymine; A, adenine). The two planar quinoxaline rings of triostin A bis intercalate on the minor groove of the DNA double helix surrounding the CG base pairs at either end. The alanine residues form hydrogen bonds to the guanines. Base stacking in the DNA is perturbed, and the major binding interaction involves a large number of van der Waals contacts between the peptides and the nucleic acid. The adenine residues in the center are in the syn conformation and are paired to thymine through Hoogsteen base pairing.

The molecular structure of a DNA-triostin A complex.,Wang AH, Ughetto G, Quigley GJ, Hakoshima T, van der Marel GA, van Boom JH, Rich A Science. 1984 Sep 14;225(4667):1115-21. PMID:6474168<ref>PMID:6474168</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
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== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Streptomyces sp]]
[[Category: Synthetic construct]]
[[Category: Hakoshima T]]
[[Category: Quigley GJ]]
[[Category: Rich A]]
[[Category: Ughetto G]]
[[Category: Van Boom JH]]
[[Category: Van Der Marel GA]]
[[Category: Wang AH-J]]