View source for 1wfw


==Solution structure of SH3 domain of mouse Kalirin-9a protein==
<StructureSection load='1wfw' size='340' side='right'caption='[[1wfw]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1wfw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WFW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WFW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wfw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wfw OCA], [https://pdbe.org/1wfw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wfw RCSB], [https://www.ebi.ac.uk/pdbsum/1wfw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wfw ProSAT], [https://www.topsan.org/Proteins/RSGI/1wfw TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KALRN_MOUSE KALRN_MOUSE] Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity (By similarity).[UniProtKB:P97924]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/1wfw_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wfw ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Inoue M]]
[[Category: Kigawa T]]
[[Category: Koshiba S]]
[[Category: Tochio N]]
[[Category: Yokoyama S]]