View source for 1wi4


==Solution structure of the PDZ domain of syntaxin binding protein 4==
<StructureSection load='1wi4' size='340' side='right'caption='[[1wi4]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1wi4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WI4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wi4 OCA], [https://pdbe.org/1wi4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wi4 RCSB], [https://www.ebi.ac.uk/pdbsum/1wi4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wi4 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wi4 TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/STXB4_MOUSE STXB4_MOUSE] Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose.<ref>PMID:10394363</ref> <ref>PMID:12855681</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wi/1wi4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wi4 ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Syntaxin-binding protein|Syntaxin-binding protein]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Endo H]]
[[Category: Hayashi F]]
[[Category: Kigawa T]]
[[Category: Tomizawa T]]
[[Category: Yokoyama S]]
[[Category: Yoshida M]]