View source for 1wik


==Solution Structure of the PICOT homology 2 domain of the mouse PKC-interacting cousin of thioredoxin protein==
<StructureSection load='1wik' size='340' side='right'caption='[[1wik]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1wik]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WIK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wik OCA], [https://pdbe.org/1wik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wik RCSB], [https://www.ebi.ac.uk/pdbsum/1wik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wik ProSAT], [https://www.topsan.org/Proteins/RSGI/1wik TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GLRX3_MOUSE GLRX3_MOUSE] Crucial regulator of cellular iron homeostasis and hemoglobin maturation (By similarity). Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. May play a role in regulating the function of the thioredoxin system. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. Has an essential function in embryogenesis.<ref>PMID:16809552</ref> <ref>PMID:18258855</ref> <ref>PMID:18929570</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wi/1wik_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wik ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Inoue M]]
[[Category: Kigawa T]]
[[Category: Koshiba S]]
[[Category: Miyamoto K]]
[[Category: Tomizawa T]]
[[Category: Yokoyama S]]