View source for 1wj1


==Solution structure of phosphotyrosine interaction domain of mouse Numb protein==
<StructureSection load='1wj1' size='340' side='right'caption='[[1wj1]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1wj1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WJ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WJ1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wj1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wj1 OCA], [https://pdbe.org/1wj1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wj1 RCSB], [https://www.ebi.ac.uk/pdbsum/1wj1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wj1 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wj1 TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NUMB_MOUSE NUMB_MOUSE] Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.<ref>PMID:10841580</ref> <ref>PMID:12410312</ref> <ref>PMID:15273690</ref> <ref>PMID:17174898</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wj/1wj1_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wj1 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Inoue M]]
[[Category: Kigawa T]]
[[Category: Koshiba S]]
[[Category: Sato M]]
[[Category: Tochio N]]
[[Category: Tomizawa T]]
[[Category: Yokoyama S]]