View source for 1wju


==Solution structure of N-terminal ubiquitin-like domain of human NEDD8 ultimate buster-1==
<StructureSection load='1wju' size='340' side='right'caption='[[1wju]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1wju]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WJU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WJU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wju OCA], [https://pdbe.org/1wju PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wju RCSB], [https://www.ebi.ac.uk/pdbsum/1wju PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wju ProSAT], [https://www.topsan.org/Proteins/RSGI/1wju TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NUB1_HUMAN NUB1_HUMAN] Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2.<ref>PMID:16707496</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wj/1wju_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wju ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Inoue M]]
[[Category: Kigawa T]]
[[Category: Koshiba S]]
[[Category: Tochio N]]
[[Category: Yokoyama S]]
[[Category: Yoneyama M]]