View source for 1wxr


==Crystal structure of Heme Binding protein, an autotransporter hemoglobine protease from pathogenic Escherichia coli==
<StructureSection load='1wxr' size='340' side='right'caption='[[1wxr]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1wxr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WXR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wxr OCA], [https://pdbe.org/1wxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wxr RCSB], [https://www.ebi.ac.uk/pdbsum/1wxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wxr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HBP_ECOLX HBP_ECOLX] Interacts with hemoglobin, degrades it and subsequently binds the released heme. Could make heme accessible not only for E.coli, but also for B.fragilis during mixed intra-abdominal infections. Has a role in abscess formation.<ref>PMID:9743528</ref> <ref>PMID:11748157</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wx/1wxr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wxr ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Heddle JG]]
[[Category: Luirink J]]
[[Category: Mizutani K]]
[[Category: Otto BR]]
[[Category: Oudega B]]
[[Category: Park S-Y]]
[[Category: Sijbrandi R]]
[[Category: Tame JRH]]