View source for 1xdx


==Solution Structure of the Tctex1 Light Chain From Chlamydomonas Inner Dynein Arm I1==
<StructureSection load='1xdx' size='340' side='right'caption='[[1xdx]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1xdx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XDX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XDX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xdx OCA], [https://pdbe.org/1xdx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xdx RCSB], [https://www.ebi.ac.uk/pdbsum/1xdx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xdx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/O64980_CHLRE O64980_CHLRE] 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xd/1xdx_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xdx ConSurf].
<div style="clear:both"></div>
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== Publication Abstract from PubMed ==
Tctex1 is a light chain found in both cytoplasmic and flagellar dyneins and is involved in many fundamental cellular activities, including rhodopsin transport within photoreceptors, and may function in the non-Mendelian transmission of t haplotypes in mice. Here, we present the NMR solution structure for the Tctex1 dimer from Chlamydomonas axonemal inner dynein arm I1. Structural comparisons reveal a strong similarity with the LC8 dynein light chain dimer, including formation of a strand-switched beta sheet interface. Analysis of the Tctex1 structure enables the dynein intermediate chain binding site to be identified and suggests a mechanism by which cargo proteins might be attached to this microtubule motor complex. Comparison with the alternate dynein light chain rp3 reveals how the specificity of dynein-cargo interactions mediated by these dynein components is achieved. In addition, this structure provides insight into the consequences of the mutations found in the t haplotype forms of this protein.

Solution structure of the Tctex1 dimer reveals a mechanism for dynein-cargo interactions.,Wu H, Maciejewski MW, Takebe S, King SM Structure. 2005 Feb;13(2):213-23. PMID:15698565<ref>PMID:15698565</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1xdx" style="background-color:#fffaf0;"></div>

==See Also==
*[[Dynein 3D structures|Dynein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Chlamydomonas reinhardtii]]
[[Category: Large Structures]]
[[Category: King SM]]
[[Category: Maciejewski MW]]
[[Category: Takebe S]]
[[Category: Wu H]]