View source for 1xy2


==CRYSTAL STRUCTURE ANALYSIS OF DEAMINO-OXYTOCIN. CONFORMATIONAL FLEXIBILITY AND RECEPTOR BINDING==
<StructureSection load='1xy2' size='340' side='right'caption='[[1xy2]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1xy2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XY2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPR:2-MERCAPTO-PROPION+ALDEHYDE'>MPR</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xy2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xy2 OCA], [https://pdbe.org/1xy2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xy2 RCSB], [https://www.ebi.ac.uk/pdbsum/1xy2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xy2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NEU1_BOVIN NEU1_BOVIN] Neurophysin 1 specifically binds oxytocin.  Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.
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== Publication Abstract from PubMed ==
Two crystal structures of deamino-oxytocin have been determined at better than 1.1A resolution from isomorphous replacement and anomalous scattering x-ray measurements. In each of two crystal forms there are two closely related conformers with disulfide bridges of different chirality, which may be important in receptor recognition and activation.

Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding.,Wood SP, Tickle IJ, Treharne AM, Pitts JE, Mascarenhas Y, Li JY, Husain J, Cooper S, Blundell TL, Hruby VJ, et al. Science. 1986 May 2;232(4750):633-6. PMID:3008332<ref>PMID:3008332</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1xy2" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Blundell TL]]
[[Category: Cooper S]]
[[Category: Pitts JE]]
[[Category: Tickle IJ]]
[[Category: Wood SP]]