View source for 1yhj


==Crystal Structure of Pyridoxal Kinase in Complex with Roscovitine and Derivatives==
<StructureSection load='1yhj' size='340' side='right'caption='[[1yhj]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1yhj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YHJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YHJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=R6C:(2R)-2-{[6-(BENZYLOXY)-9-ISOPROPYL-9H-PURIN-2-YL]AMINO}BUTAN-1-OL'>R6C</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yhj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yhj OCA], [https://pdbe.org/1yhj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yhj RCSB], [https://www.ebi.ac.uk/pdbsum/1yhj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yhj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDXK_SHEEP PDXK_SHEEP] Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yh/1yhj_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yhj ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Pyridoxal kinase|Pyridoxal kinase]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Ovis aries]]
[[Category: Bach S]]
[[Category: Cao P]]
[[Category: Chang W-R]]
[[Category: Ferandin Y]]
[[Category: Galons H]]
[[Category: Gray N]]
[[Category: Jiang T]]
[[Category: Koken M]]
[[Category: Li M-H]]
[[Category: Liang D-C]]
[[Category: Meijer L]]
[[Category: Reinhardt J]]
[[Category: Tang L]]
[[Category: Wan Y]]
[[Category: Wang F]]