View source for 1yq6


==PRD1 vertex protein P5==
<StructureSection load='1yq6' size='340' side='right'caption='[[1yq6]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1yq6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterobacteria_phage_PRD1 Enterobacteria phage PRD1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YQ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YQ6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yq6 OCA], [https://pdbe.org/1yq6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yq6 RCSB], [https://www.ebi.ac.uk/pdbsum/1yq6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yq6 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Comparisons of bacteriophage PRD1 and adenovirus protein structures and virion architectures have been instrumental in unraveling an evolutionary relationship and have led to a proposal of a phylogeny-based virus classification. The structure of the PRD1 spike protein P5 provides further insight into the evolution of viral proteins. The crystallized P5 fragment comprises two structural domains: a globular knob and a fibrous shaft. The head folds into a ten-stranded jelly roll beta barrel, which is structurally related to the tumor necrosis factor (TNF) and the PRD1 coat protein domains. The shaft domain is a structural counterpart to the adenovirus spike shaft. The structural relationships between PRD1, TNF, and adenovirus proteins suggest that the vertex proteins may have originated from an ancestral TNF-like jelly roll coat protein via a combination of gene duplication and deletion.

The structure of the bacteriophage PRD1 spike sheds light on the evolution of viral capsid architecture.,Merckel MC, Huiskonen JT, Bamford DH, Goldman A, Tuma R Mol Cell. 2005 Apr 15;18(2):161-70. PMID:15837420<ref>PMID:15837420</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1yq6" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Enterobacteria phage PRD1]]
[[Category: Large Structures]]
[[Category: Bamford DH]]
[[Category: Goldman A]]
[[Category: Huiskonen JT]]
[[Category: Merckel MC]]
[[Category: Tuma R]]