View source for 1yu0


==Major Tropism Determinant P1 Variant==
<StructureSection load='1yu0' size='340' side='right'caption='[[1yu0]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1yu0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bordetella_virus_BPP1 Bordetella virus BPP1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YU0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YU0 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yu0 OCA], [https://pdbe.org/1yu0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yu0 RCSB], [https://www.ebi.ac.uk/pdbsum/1yu0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yu0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FIBD_BPBPP FIBD_BPBPP] Tail fiber protein located at the distal ends of the fibers that binds to the adhesion receptors on the host surface, thereby determining the host range. The phage can alter its tropism by modifying this protein. Variants are expressed through a diversity-generating retroelement (DGR) that creates mutant copies of a template repeat and replaces the end of the tail fiber receptor-binding protein with these sequences, thus changing the host range. Milliards of variants of the fiber receptor-binding protein can be created with this system.<ref>PMID:15386016</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bordetella virus BPP1]]
[[Category: Large Structures]]
[[Category: Ghosh P]]
[[Category: Lawton JA]]
[[Category: McMahon SA]]
[[Category: Miller JL]]