View source for 21aw


==Crystal structure of Nicotiana benthamiana importin alpha-Cucumber mosaic virus (strain FNY) suppressor of silencing 2b NLS peptide complex==
<StructureSection load='21aw' size='340' side='right'caption='[[21aw]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[21aw]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Cucumber_mosaic_virus_(strain_FNY) Cucumber mosaic virus (strain FNY)] and [https://en.wikipedia.org/wiki/Nicotiana_benthamiana Nicotiana benthamiana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=21AW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=21AW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=21aw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=21aw OCA], [https://pdbe.org/21aw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=21aw RCSB], [https://www.ebi.ac.uk/pdbsum/21aw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=21aw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/2B_CMVFN 2B_CMVFN] Multifunctional protein that plays two independent roles: viral suppressor of host RNAi (VSR) and viral inducer of host attractiveness to insect vectors (VIA). Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (PubMed:25380036). May directly interfere with mobile silencing signaling (By similarity). Also inhibits signal transduction by the phytohormone jasmonate, making the infected plant more attractive to aphids, which are the second host to play a role as a dissemination vector. Acts by binding to and inhibiting JAZ degradation in the host (By similarity).[UniProtKB:Q66125]<ref>PMID:25380036</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Nicotiana benthamiana]]
[[Category: Chen Z]]
[[Category: Liu Y]]