View source for 21gf


==Structure of the heptameric pore state of alpha-hemolysin in the presence of A549 cells at pH 5.5==
<StructureSection load='21gf' size='340' side='right'caption='[[21gf]], [[Resolution|resolution]] 3.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[21gf]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=21GF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=21GF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.75&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=21gf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=21gf OCA], [https://pdbe.org/21gf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=21gf RCSB], [https://www.ebi.ac.uk/pdbsum/21gf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=21gf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HLA_STAAU HLA_STAAU] Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Chatterjee A]]
[[Category: Dutta S]]