View source for 21gm


==Structure of the GPI-AP transporter in state1==
<StructureSection load='21gm' size='340' side='right'caption='[[21gm]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[21gm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=21GM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=21GM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=21gm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=21gm OCA], [https://pdbe.org/21gm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=21gm RCSB], [https://www.ebi.ac.uk/pdbsum/21gm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=21gm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TMED9_HUMAN TMED9_HUMAN] Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB.<ref>PMID:10852829</ref> <ref>PMID:14600267</ref> <ref>PMID:16595549</ref> <ref>PMID:18287528</ref> <ref>PMID:19296914</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Hua ZK]]
[[Category: Yu HJ]]
[[Category: Zhang D]]
[[Category: Zhang M]]