View source for 21nj


==Crystal structure of compound 10 bound to human Nicotinamide N-methyltransferase==
<StructureSection load='21nj' size='340' side='right'caption='[[21nj]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[21nj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=21NJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=21NJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1MDA:(3~{S})-~{N}-(2-oxidanylidene-3~{H}-1,3-benzothiazol-7-yl)-1-(2-pyridin-2-ylethyl)piperidine-3-carboxamide'>A1MDA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=21nj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=21nj OCA], [https://pdbe.org/21nj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=21nj RCSB], [https://www.ebi.ac.uk/pdbsum/21nj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=21nj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NNMT_HUMAN NNMT_HUMAN] Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Kitade M]]
[[Category: Kondo N]]
[[Category: Sako Y]]
[[Category: Tachibana Y]]
[[Category: Uehara S]]
[[Category: Yamamoto S]]
[[Category: Yoshida S]]
[[Category: Yoshimura N]]