View source for 22dz


==Local structure of MERS-CoV RBD protein bound with receptor DPP4 in the conformation 2 (2 up RBD and 2 DPP4 bound)==
<StructureSection load='22dz' size='340' side='right'caption='[[22dz]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[22dz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Betacoronavirus_England_1 Betacoronavirus England 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=22DZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=22DZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.01&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=22dz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=22dz OCA], [https://pdbe.org/22dz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=22dz RCSB], [https://www.ebi.ac.uk/pdbsum/22dz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=22dz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SPIKE_MERS1 SPIKE_MERS1] Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Interacts with host DPP4 to mediate virla entry.[HAMAP-Rule:MF_04099]<ref>PMID:23486063</ref>   Mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099]  Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Betacoronavirus England 1]]
[[Category: Large Structures]]
[[Category: Sun L]]
[[Category: Wang YJ]]