View source for 22jz


==Cryo-EM structure of the mGlu7-beta-arrestin 1 complex==
<StructureSection load='22jz' size='340' side='right'caption='[[22jz]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[22jz]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=22JZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=22JZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=22jz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=22jz OCA], [https://pdbe.org/22jz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=22jz RCSB], [https://www.ebi.ac.uk/pdbsum/22jz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=22jz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GRM7_HUMAN GRM7_HUMAN] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.<ref>PMID:9473604</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Chen K]]
[[Category: Chu X]]
[[Category: Feng Y]]
[[Category: Han S]]
[[Category: Lin S]]
[[Category: Ma L]]
[[Category: Wang Z]]
[[Category: Wei J]]
[[Category: Wu B]]
[[Category: Yi C]]
[[Category: Zhang C]]
[[Category: Zhao Q]]